Cardiac Arrest

An experimental study was performed using an established model of cardiac arrest. Cardiopulmonary resuscitation was commenced immediately after drug administration and defibrillation was attempted. In one group drug treatment was a bolus dose of adrenaline and in the other group a bolus dose of adrenaline with centhaquine was administered.

Return of spontaneous circulation (ROSC) was observed in 10 out of 10 (100%) animals treated with centhaquine compared to 4 out of 10 (40%) animals in the control group and all the animals treated with centhaquine survived for 24 hours.

Centhaquine treated animal had significantly higher coronary perfusion pressure compared to control.

Centhaquine has already gone through extensive human studies and is in market for hypovolemic shock. We are planning to explore clinical evaluation of centhaquine in cardiac arrest patients.

Product	Pre-Clinical	Clinical	Market
Cardiac Arrest (Centhaquine)

Product

Pre-Clinical

Clinical

Market

Phase 1

Phase 2

Phase 3

Cardiac Arrest (Centhaquine)

#	Publication List
	Papalexopoulou, K., Chalkias, A., Pliatsika, P., Papalois, A., Papapanagiotou, P., Papadopoulos, G., Arnaoutoglou, E., Petrou, A., Gulati, A., and Xanthos, T. (2017) Centhaquin Effects in a Swine Model of Ventricular Fibrillation: Centhaquin and Cardiac Arrest. Heart Lung Circ 26, 856-863
	Galatianou, I., Karlis, G., Apostolopoulos, A., Intas, G., Chalari, E., Gulati, A., Iacovidou, N., Chalkias, A., and Xanthos, T. (2017) Body mass index and outcome of out-of-hospital cardiac arrest patients not treated by targeted temperature management. Am J Emerg Med 35, 1247-1251
	Varvarousis, D., Varvarousi, G., Iacovidou, N., D'Aloja, E., Gulati, A., and Xanthos, T. (2015) The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management. Am J Emerg Med 33, 1297-1304
	Kakavas, S., Mongardon, N., Cariou, A., Gulati, A., and Xanthos, T. (2015) Early-onset pneumonia after out-of-hospital cardiac arrest. J Infect 70, 553-562
	Chalkias, A., Fanos, V., Noto, A., Castren, M., Gulati, A., Svavarsdottir, H., Iacovidou, N., and Xanthos, T. (2014) 1H NMR-metabolomics: can they be a useful tool in our understanding of cardiac arrest? Resuscitation 85, 595-601

Publication List

Papalexopoulou, K., Chalkias, A., Pliatsika, P., Papalois, A., Papapanagiotou, P., Papadopoulos, G., Arnaoutoglou, E., Petrou, A., Gulati, A., and Xanthos, T. (2017) Centhaquin Effects in a Swine Model of Ventricular Fibrillation: Centhaquin and Cardiac Arrest. Heart Lung Circ 26, 856-863

Galatianou, I., Karlis, G., Apostolopoulos, A., Intas, G., Chalari, E., Gulati, A., Iacovidou, N., Chalkias, A., and Xanthos, T. (2017) Body mass index and outcome of out-of-hospital cardiac arrest patients not treated by targeted temperature management. Am J Emerg Med 35, 1247-1251

Varvarousis, D., Varvarousi, G., Iacovidou, N., D'Aloja, E., Gulati, A., and Xanthos, T. (2015) The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management. Am J Emerg Med 33, 1297-1304

Kakavas, S., Mongardon, N., Cariou, A., Gulati, A., and Xanthos, T. (2015) Early-onset pneumonia after out-of-hospital cardiac arrest. J Infect 70, 553-562

Chalkias, A., Fanos, V., Noto, A., Castren, M., Gulati, A., Svavarsdottir, H., Iacovidou, N., and Xanthos, T. (2014) 1H NMR-metabolomics: can they be a useful tool in our understanding of cardiac arrest? Resuscitation 85, 595-601

Status of Cardiac Arrest

Publications