An experimental study was performed using an established model of cardiac arrest. Cardiopulmonary resuscitation was commenced immediately after drug administration and defibrillation was attempted. In one group drug treatment was a bolus dose of adrenaline and in the other group a bolus dose of adrenaline with centhaquine was administered.
Return of spontaneous circulation (ROSC) was observed in 10 out of 10 (100%) animals treated with centhaquine compared to 4 out of 10 (40%) animals in the control group and all the animals treated with centhaquine survived for 24 hours.
Centhaquine treated animal had significantly higher coronary perfusion pressure compared to control.
Centhaquine has already gone through extensive human studies and is in market for hypovolemic shock. We are planning to explore clinical evaluation of centhaquine in cardiac arrest patients.