Post Operative Pain

PMZ-2010, produced a dose-dependent reduction in post operative pain.

It may be a novel alternative to morphine treatment in post operative surgical pain.

It does not have sedative effect, no action on opiate receptors. Risk of respiratory depression is minimal.

PMZ-2010 has mild and short lived hypotensive and bradycardia action therefore less risk of severe fall in blood pressure as compared to clonidine or dexmedetomidine. It does not produce hypothermia as observed with clonidine.

PMZ-2010 has successfully completed human Phase I study (NCT02408731; CTRI/2014/06/004647).

Status of Post Operative Pain


phase 1

phase 2

phase 3


Post Operative Pain



  • Leonard, M. G., Jung, S., Andurkar, S. V., and Gulati, A. (2016) Centhaquin attenuates hyperalgesia and non-evoked guarding in a rat model of postoperative pain primarily through alpha2B-adrenoceptors. Eur J Pharmacol 789, 81-87
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  • Leonard, M. G., Jung, S., Andurkar, S. V., and Gulati, A. (2014) Centhaquin Produces Dose-dependent Antinociception in a Rat Model of Post-operative Pain. Clin Pharmacol in Drug Develop 3, 52-53.
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  • Bhalla, S., Ali, I., Andurkar, S. V., and Gulati, A. (2013) Centhaquin antinociception in mice is mediated by alpha2A- and alpha2B- but not alpha2C-adrenoceptors. Eur J Pharmacol 715, 328-336
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  • Andurkar, S. V., and Gulati, A. (2011) Assessment of the analgesic effect of centhaquin in mouse tail flick and hot-plate tests. Pharmacology 88, 233-241
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