An experimental study was performed using an established model of cardiac arrest and a bolus dose of adrenaline was administered with or without PMZ-2010. Cardiopulmonary resuscitation was commenced immediately after drug administration and defibrillation was attempted.
PMZ-2010 treated animals regained return of spontaneous circulation in 10 out of 10 (100%) compared to 4 out of 10 (40%) control and all subjects that regained return of spontaneous circulation survived for 24 hours.
PMZ-2010 subjects had significantly higher coronary perfusion pressure compared to control.
PMZ-2010 has successfully completed human Phase I study (NCT02408731; CTRI/2014/06/004647) was found to be safe and was well tolerated.
Cardiac Arrest (PMZ-2010)