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Cardiac Arrest

An experimental study was performed using an established model of cardiac arrest and a bolus dose of adrenaline was administered with or without PMZ-2010. Cardiopulmonary resuscitation was commenced immediately after drug administration and defibrillation was attempted.

PMZ-2010 treated animals regained return of spontaneous circulation in 10 out of 10 (100%) compared to 4 out of 10 (40%) control and all subjects that regained return of spontaneous circulation survived for 24 hours.

PMZ-2010 subjects had significantly higher coronary perfusion pressure compared to control.

PMZ-2010 has successfully completed human Phase I study (NCT02408731; CTRI/2014/06/004647) was found to be safe and was well tolerated.

Status of Cardiac Arrest

Product
Pre-Clinical
Clinical

phase 1

phase 2

phase 3

market

Cardiac Arrest (PMZ-2010)

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Publications

  • Papalexopoulou, K., Chalkias, A., Pliatsika, P., Papalois, A., Papapanagiotou, P., Papadopoulos, G., Arnaoutoglou, E., Petrou, A., Gulati, A., and Xanthos, T. (2017) Centhaquin Effects in a Swine Model of Ventricular Fibrillation: Centhaquin and Cardiac Arrest. Heart Lung Circ 26, 856-863
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  • Galatianou, I., Karlis, G., Apostolopoulos, A., Intas, G., Chalari, E., Gulati, A., Iacovidou, N., Chalkias, A., and Xanthos, T. (2017) Body mass index and outcome of out-of-hospital cardiac arrest patients not treated by targeted temperature management. Am J Emerg Med 35, 1247-1251
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  • Varvarousis, D., Varvarousi, G., Iacovidou, N., D'Aloja, E., Gulati, A., and Xanthos, T. (2015) The pathophysiologies of asphyxial vs dysrhythmic cardiac arrest: implications for resuscitation and post-event management. Am J Emerg Med 33, 1297-1304
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  • Kakavas, S., Mongardon, N., Cariou, A., Gulati, A., and Xanthos, T. (2015) Early-onset pneumonia after out-of-hospital cardiac arrest. J Infect 70, 553-562
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  • Chalkias, A., Fanos, V., Noto, A., Castren, M., Gulati, A., Svavarsdottir, H., Iacovidou, N., and Xanthos, T. (2014) 1H NMR-metabolomics: can they be a useful tool in our understanding of cardiac arrest? Resuscitation 85, 595-601
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