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Spinal Cord Injury

It is now known that progenitor stem cells are present and neurogenesis can occur in the spinal cord.

Several models of spinal cord injury have demonstrated neurogenesis after injury.

In vitro studies show that endothelin B receptor agonist, PMZ-1620, treatment enhances neurogenesis and neuronal re-networking following spinal cord injury.

In vivo studies show that PMZ-1620 significantly improves motor function recovery after spinal cord injury in rat.

Clinical stage – Phase I completed.

Status of Spinal Cord Injury

Product
Pre-Clinical
Clinical

phase 1

phase 2

phase 3

market

Spinal Cord Injury(PMZ-1620)

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Publications

  • Leonard, M. G., Prazad, P., Puppala, B., and Gulati, A. (2015) Selective Endothelin-B Receptor Stimulation Increases Vascular Endothelial Growth Factor in the Rat Brain during Postnatal Development. Drug Res (Stuttg) 65, 607-613
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  • Gulati, A. (2015) Understanding neurogenesis in the adult human brain. Indian J Pharmacol 47, 583-584
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