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Neurovascular Diseases

  • Briyal, S., Shepard, C. and Gulati, A. Endothelin receptor type B agonist, IRL-1620, prevents beta amyloid (Aβ) induced oxidative stress and cognitive impairment in normal and diabetic rats. Pharmacology, Biochemistry and Behavior 2014; 120:65-72. PubMed PMID: 24561065.
  • Leonard, M.G. and Gulati, A. Endothelin B Receptor Agonist, IRL-1620, Enhances Angiogenesis and Neurogenesis Following Cerebral Ischemia in Rats. Brain Research 2013; 1528: 28-41. PubMed PMID: 23850649.
  • Puppala, B., Awan, I., Briyal, S., Mbachu, O., Leonard, M. and Gulati, A. Ontogeny of endothelin receptors in the brain, heart, and kidneys of neonatal rats at different postnatal ages. Brain and Development 2014 May 8. pii: S0387-7604(14)00115-6. doi: 10.1016/j.braindev.2014.04.008. PubMed PMID: 24815227.
  • Briyal, S., Lavhale, M.S. and Gulati, A. Repeated administration of centhaquin to pregnant rats did not affect postnatal development and expression of endothelin receptors in the brain, heart or kidney of pups. Arzneimittelforschung. 2012; 62(12): 670-6. PubMed PMID: 23154885.
  • Leonard, M.G., Briyal, S., and Gulati, A. Endothelin B receptor agonist, IRL-1620, provides long-term neuroprotection in cerebral ischemia in rats. Brain Research 2012; 1464: 14-23. PubMed PMID: 22580085.
  • Kaundal, R.K., Deshpande, T., Gulati, A. and Sharma, S.S. Targeting Endothelin Receptors for Pharmacotherapy of Ischemic Stroke: Current Scenario and Future perspectives. Drug Discovery Today 2012 (Epub March). PubMed PMID: 22406696.
  • Leonard, M.G., Briyal, S. and Gulati, A. Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats. Brain Research 2011; 1420: 48-58. PubMed PMID: 21959172.
  • Briyal, S., Philip, T. and Gulati, A. Endothelin-A receptor antagonists prevent beta-amyloid induced increase in ETA receptor expression, oxidative stress and cognitive impairment. Journal Alzheimer’s Disease 2011; 23: 491-503. PubMed PMID: 21116051.
  • Briyal, S. and Gulati, A. Endothelin antagonist BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. European J. Pharmacology, 2010; 644: 73-79. PubMed PMID: 20638381.
  • Leonard, M.G. and Gulati, A. Repeated administration of ETB receptor agonist, IRL-1620, produces tachyphylaxis only to its hypotensive effect. Pharmacological Research 2009 60: 402-410. PubMed PMID: 19666119.
  • Briyal S, Gulati A, Gupta YK. Effect of combination of endothelin receptor antagonist (TAK-044) and aspirin in middle cerebral artery occlusion model of acute ischemic stroke in rats. Methods Find Exp Clin Pharmacol 2007;29(4):257-63. PubMed PMID: 17609737.
  • Gupta YK, Briyal S, Sharma U, Jagannathan NR, Gulati A. Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats. Life Sci 2005;77(1):15-27. PubMed PMID: None.
  • Rebello S, Singh G, Gulati A. Elevated levels of endothelin-1 following unilateral cerebral-ischemia in rats. Faseb Journal 1995;9(4):A937-A. PubMed PMID: None.